Complete Blood Count (CBC) with Differential
What it measures
A CBC measures red blood cells, white blood cells, platelets, hemoglobin, and hematocrit. The 'with Differential' part breaks down the white blood cells into their five types — useful for identifying infections, inflammation, and certain blood disorders.
When it’s ordered
Routine physicals, fatigue workups, suspected infections, monitoring chemotherapy, follow-up on prior abnormal results.
Medicare coverage
Governed by NCD 190.15 (Blood Counts). This national rule works in reverse from most. It lists the diagnoses that do NOT support the test, and a claim billed with one of them can be denied. A general "routine exam" reason may not justify the test by itself; a specific symptom or condition helps.
Typical price
Medicare allowable runs around $7–11. Commercial cash prices range from $15 to $90 depending on the lab.
One thing to watch
Use the Test Lookup tool for the full list of accepted ICD-10 codes in your state.
Look up the current Medicare allowable for Complete Blood Count (CBC) with Differential →
Rates and coverage rules shown apply to Original Medicare (Fee-for-Service) only. Medicare Advantage plans may differ. See our data sources →